Regenerative Orthobiologics

Regenerative Orthobiologics · Long Beach, CA

Biologic treatment options for orthopedic care

Regenerative orthobiologics encompass a range of biologically derived treatment options considered for appropriate candidates — evaluated through thorough orthopedic assessment, not offered as a blanket solution.
Board-certified orthopedic surgeon Candidacy-based evaluation Non-surgical pathways

What are regenerative orthobiologics?

Orthobiologics are substances derived from biological sources — including bone marrow, adipose tissue, amniotic material, and other cell-based products — used to support musculoskeletal healing. They represent a growing area of orthopedic research and clinical application.
 
Dr. Matthewson approaches orthobiologic treatment with the same diagnostic rigor applied to all care decisions. Appropriateness is determined by your specific condition, imaging, history, and goals — not by a standard protocol.

Orthobiologic options discussed at this practice

Platelet-Rich Plasma (PRP)

Concentrated platelets from the patient's own blood — see dedicated PRP page for full detail

Bone Marrow Aspirate Concentrate (BMAC)

Stem cell-rich material harvested from the patient's own bone marrow for joint and tissue support

Microfat Grafting Offered here

Adipose-derived tissue harvested from the patient's own fat via minimally invasive procedure and processed for injection — contains naturally occurring regenerative cellular components

Amniotic / Birth Tissue Allografts

Tissue-derived biologics used to support joint and soft tissue environments where appropriate

Exosome Therapy

Cell-signaling molecules that may support tissue repair and reduce inflammatory response — emerging area of application

Conditions patients explore orthobiologics for

Advanced knee osteoarthritis
Cartilage loss or damage
Chronic rotator cuff conditions
Hip joint degeneration
Desire to delay joint replacement
Post-surgical tissue healing

Is this right for you? That requires an evaluation.

Orthobiologic treatments are among the more complex regenerative options available. Dr. Matthewson will give you an honest orthopedic opinion — including whether a biologic approach makes sense or whether another pathway is more appropriate.
 

Patients who have not responded to conventional non-surgical treatment

Those seeking to avoid or meaningfully delay surgery

Patients wanting a board-certified orthopedic opinion on biologic options

Active adults with significant joint conditions affecting quality of life

Common questions about orthobiologics

PRP (platelet-rich plasma) is one type of orthobiologic treatment. Orthobiologics is a broader category that includes PRP as well as other regenerative therapies that use natural biological materials to support healing. While PRP focuses on concentrated platelets from your blood, other orthobiologics may involve different components designed to enhance tissue repair and reduce inflammation.

Microfat grafting involves using a small amount of your own fat tissue, which contains regenerative cells and healing factors, to support tissue repair. Unlike traditional “stem cell therapy,” which is often marketed broadly, microfat grafting uses minimally processed tissue in a way that aligns with current medical guidelines. Your provider will determine the most appropriate option based on your condition and goals.

Many regenerative procedures use your body’s own cells and are considered FDA-compliant, but their use for certain conditions may be classified as off-label. This is common in many areas of medicine. All treatments are performed following current safety standards, and your provider will explain how they apply to your specific situation.

The best way to determine if you’re a candidate is through a consultation. In general, patients with mild to moderate joint pain, soft tissue injuries, or early degeneration may benefit most from regenerative therapies. We’ll evaluate your condition, medical history, and goals to recommend the most appropriate treatment plan.

Orthobiologic treatments are typically considered elective and are not covered by most insurance plans. However, many patients choose these therapies as a way to potentially reduce the need for surgery or long-term medication. We’ll review costs and available options with you during your consultation.

Most regenerative procedures are performed in-office and involve collecting a small sample of your own blood or tissue, processing it, and then precisely injecting it into the targeted area. The process is typically minimally invasive and designed to support your body’s natural healing response.

Recovery time is generally short compared to surgery. You may experience mild soreness or swelling for a few days after the procedure, but most patients return to normal daily activities within 24–48 hours. Your provider may recommend temporarily limiting strenuous activity to optimize healing.

Get an orthopedic opinion on your options

If you’re considering regenerative treatment, the right starting point is an honest evaluation — not a sales consultation. Dr. Matthewson will assess your condition and tell you what makes sense.